Gizdulich P
Clinical Physiopathology Department, Florence University, Italy.
Med Biol Eng Comput. 1992 May;30(3):351-6. doi: 10.1007/BF02446974.
An alternative to whole body plethysmography is proposed for estimating upper airway resistance. The feasibility study indicates that the method should be suitable for diagnostic and clinical purposes, following a proper survey and the testing of its reproducibility. 11 subjects are asked to breath normally through 12 small resistances while flow and pressure are monitored at the mouth. Chest movements are recorded by sampling a chest cross-section, and relative variations of the cross-section are compared to the expired and inspired volumes. No viscoelastic effects are significantly documented so that in a first approximation a model consisting only of resistors is applied to the airways. In each subject the patterns of the flow and mouth-pressure are heuristically estimated as a polynomial function of the added resistance. From the fit of the resistor model, the internal resistance of the airways is estimated as that value able to link the flow-resistance function to the pressure-resistance function, according to the classic Kirchhoff laws. We obtain resistances of (mean resistance +/- SD) 2.9 +/- 1.1, range 1.1 to 5.2, hPasdm-3 during expiration and 2.5 +/- 0.8, range 1.3 to 3.7, hPasdm-3 during inspiration.
本文提出了一种用于估计上气道阻力的全身体积描记法替代方法。可行性研究表明，经过适当的调查及其可重复性测试后，该方法应适用于诊断和临床目的。要求11名受试者通过12个小阻力进行正常呼吸，同时监测口腔处的流量和压力。通过对胸部横截面进行采样来记录胸部运动，并将横截面的相对变化与呼出和吸入体积进行比较。没有明显记录到粘弹性效应，因此在一阶近似中，仅由电阻器组成的模型被应用于气道。在每个受试者中，流量和口腔压力模式被启发式地估计为附加阻力的多项式函数。根据经典基尔霍夫定律，从电阻器模型的拟合中，气道的内阻被估计为能够将流量-阻力函数与压力-阻力函数联系起来的值。我们在呼气期间获得的阻力为（平均阻力±标准差）2.9±1.1，范围为1.1至5.2，hPasdm-3；在吸气期间为2.5±0.8，范围为1.3至3.7，hPasdm-3。
