Oliver J W, Waldrop V
J Am Vet Med Assoc. 1983 Mar 1;182(5):486-9.
A study was designed to assess the secretory response of thyroid glands in dogs to small doses of thyrotropin (thyroid-stimulating hormone, TSH; 2.5 and 5.0 units, total IV dose), and to establish valid blood-sampling periods in cases in which thyroxine concentrations were different from base-line values. Significant (P less than 0.001) response occurred as early as 3 hours after TSH administration, with peak response at 5 to 7 hours. Fasting dogs for 12 hours had no effect on test results. Because base-line thyroxine concentrations in dogs are equivocal and base-line triiodothyronine concentrations are influenced by many factors, thyrotropin stimulation testing is one of the best methods at present to evaluate thyroid function. Administration of a total dose of 2.5 to 5.0 units of TSH is economical, and collection of the 2nd blood sample as early as 3 hours for response may be advantageous in terms of scheduling for the client and practicing veterinarian.
一项研究旨在评估犬甲状腺对小剂量促甲状腺素（促甲状腺激素，TSH；静脉注射总剂量2.5和5.0单位）的分泌反应，并在甲状腺素浓度与基线值不同的情况下确定有效的采血时间。TSH给药后3小时最早出现显著（P小于0.001）反应，5至7小时达到反应峰值。禁食12小时的犬对测试结果无影响。由于犬的基线甲状腺素浓度不明确，且基线三碘甲状腺原氨酸浓度受多种因素影响，促甲状腺素刺激试验是目前评估甲状腺功能的最佳方法之一。给予2.5至5.0单位的TSH总剂量较为经济，早在3小时采集第二份血样以检测反应，在为客户和执业兽医安排时间方面可能具有优势。
