Lorenz M D, Stiff M E
J Am Vet Med Assoc. 1980 Jul 1;177(1):78-81.
Thyroid function in 39 dogs was studied, utilizing serum thyroxine (T-4) analysis before and 10 hours after thyroid-stimulating hormone (TSH) stimulation. All dogs were treated with pharmacologic doses of L-thyroxine or liothyronine, and the dogs' responses to these treatments were documented. Failure to double control T-4 values after TSH administration was associated with a good response to thyroid medication, whereas a doubling of the control values after TSH administration was associated with negative responses to thyroid medication. Significant difference was not found in the control T-4 values of the various groups, whereas the post-TSH values were significantly different. The study substantiated the value of TSH-response tests in the presumptive diagnosis of canine hypothyroidism.
对39只犬的甲状腺功能进行了研究，采用促甲状腺激素（TSH）刺激前后的血清甲状腺素（T-4）分析。所有犬均接受药理剂量的左旋甲状腺素或碘塞罗宁治疗，并记录犬对这些治疗的反应。TSH给药后对照T-4值未翻倍与对甲状腺药物的良好反应相关，而TSH给药后对照值翻倍与对甲状腺药物的阴性反应相关。各组的对照T-4值未发现显著差异，而TSH给药后的数值有显著差异。该研究证实了TSH反应试验在犬甲状腺功能减退症推定诊断中的价值。
