3 - O - 去甲基 - 2,3 - 二表 - 福提米星和3 - O - 去甲基 - 3 - 表 - 福提米星

3-O-demethyl-2,3-di-epi-fortimicins and 3-O-demethyl-3-epi-fortimicins.

作者信息

Tadanier J, Hallas R

出版信息

J Antibiot (Tokyo). 1983 Mar;36(3):256-66. doi: 10.7164/antibiotics.36.256.

DOI:10.7164/antibiotics.36.256

Abstract

Syntheses of the 3-O-demethyl-2,3-di-epi-fortimicins A and B and the 3-O-demethyl-3-epi-fortimicins A and B have been accomplished in processes the key steps of which were solvolyses of 4-N-acetyl-3-O-demethyl-3-O-methanesulfonylfortimicin derivatives. Antibacterial activities of the new antibiotics are reported.

摘要

已通过关键步骤为4-N-乙酰基-3-O-去甲基-3-O-甲磺酰基福提米星衍生物溶剂解反应的过程完成了3-O-去甲基-2,3-二表-福提米星A和B以及3-O-去甲基-3-表-福提米星A和B的合成。报道了这些新型抗生素的抗菌活性。