Flor S C
J Chromatogr. 1983 Feb 11;272(2):315-23. doi: 10.1016/s0378-4347(00)86134-4.
A method is described for the quantitation of flunarizine in biological fluids including plasma, urine, milk, fecal and tissue homogenates using the analogue cinnarizine as the internal standard. As little as 1.5 ng of flunarizine per ml of plasma can be accurately quantitated, this being achieved by the combination of a selective extraction procedure and a nitrogen detector. The method has been used to determine the concentration of flunarizine in biological fluids in support of human and animal pharmacokinetic studies.
描述了一种使用类似物桂利嗪作为内标物，对生物流体（包括血浆、尿液、乳汁、粪便和组织匀浆）中的氟桂利嗪进行定量的方法。每毫升血浆中低至1.5纳克的氟桂利嗪都能被准确定量，这是通过选择性萃取程序和氮检测器相结合实现的。该方法已用于测定生物流体中氟桂利嗪的浓度，以支持人体和动物的药代动力学研究。
