Thomson N C, O'Byrne P, Hargreave F E
J Allergy Clin Immunol. 1983 Apr;71(4):357-62. doi: 10.1016/0091-6749(83)90062-3.
The pattern of asthmatic response after inhalation of atropine and methacholine was studied in six adult asthmatics. After pretreatment with atropine, the provocation concentration of methacholine to cause a fall in FEV1 of 20% was increased from 0.66 +/- 2.09 to 94.90 +/- 1.78 mg/ml. In the subsequent 7 hr, four subjects developed prolonged asthmatic responses. These occurred after concentrations of methacholine higher than those used clinically but did not directly relate to the dose of methacholine or to the increase in dose after atropine. In one subject the prolonged response was not accompanied by increased methacholine responsiveness and was not prevented by pretreatment with cromolyn sodium (40 mg). These results show that high doses of methacholine inhaled after pretreatment with atropine can induce prolonged asthmatic responses but the mechanism is unclear.
对6名成年哮喘患者吸入阿托品和乙酰甲胆碱后的哮喘反应模式进行了研究。用阿托品预处理后，使第一秒用力呼气容积（FEV1）下降20%的乙酰甲胆碱激发浓度从0.66±2.09mg/ml增加到94.90±1.78mg/ml。在随后的7小时内，4名受试者出现了延长的哮喘反应。这些反应发生在高于临床使用浓度的乙酰甲胆碱之后，但与乙酰甲胆碱的剂量或阿托品后剂量的增加没有直接关系。在一名受试者中，延长的反应并未伴有乙酰甲胆碱反应性增加，且色甘酸钠（40mg）预处理未能预防。这些结果表明，用阿托品预处理后吸入高剂量的乙酰甲胆碱可诱发延长的哮喘反应，但其机制尚不清楚。
