McIntyre E, Fitzgibbon B, Otto H, Minson R, Alpers J, Ruffin R
J Allergy Clin Immunol. 1983 Apr;71(4):375-81. doi: 10.1016/0091-6749(83)90065-9.
Fifteen asthmatic subjects participated in a double-blind trial comparing the protective effects of inhaled verapamil, salbutamol, and saline against inhaled histamine. Inhaling verapamil between four repeated histamine inhalation tests produced no significant protection against histamine-induced bronchoconstriction, while there was significant protection with salbutamol (p less than 0.001). Inhaling verapamil before a single inhalation test produced limited but significant protection (p less than 0.05) compared with a saline control in eight asthmatic subjects. This small protective effect in the two-treatment study of eight asthmatics suggests that either the protective effect of verapamil is variable among subjects or a preceding histamine inhalation test blocks the verapamil effect.
15名哮喘患者参与了一项双盲试验，比较吸入维拉帕米、沙丁胺醇和生理盐水对吸入组胺的保护作用。在四次重复组胺吸入试验之间吸入维拉帕米，对组胺诱导的支气管收缩没有显著的保护作用，而沙丁胺醇则有显著的保护作用（p<0.001）。在单次吸入试验前吸入维拉帕米，与生理盐水对照组相比，在8名哮喘患者中产生了有限但显著的保护作用（p<0.05）。在对8名哮喘患者进行的双治疗研究中的这种小的保护作用表明，要么维拉帕米的保护作用在受试者之间存在差异，要么先前的组胺吸入试验会阻断维拉帕米的作用。
