Krivoy N, Brandt H D, Bunn A E
Respiration. 1985;47(3):185-9. doi: 10.1159/000194767.
Submaximal histamine dose-response curves were obtained on 34 dogs divided into six groups. These groups were: A (n = 6) untreated; B (n = 6) after atropine (1 mg/kg); C (n = 5) after verapamil inhalation (10 mg total dose); D (n = 5) after verapamil inhalation (100 mg total dose); E and F (n = 6) as for C and D but pre-treated with atropine (1 mg/kg). Total lung resistance (R1) was measured in each case at increasing delivered concentrations of inhaled histamine and expressed as a ratio of baseline valve. For each group a composite mean curve was obtained and the maximal recorded responses (mean maximal resistance ratios) for the various groups were compared. It appears that the combination of verapamil inhalation (low dose) and atropine reduced the anticholinergic effect of atropine causing marked bronchoconstriction. This unexpected result depends on the verapamil dose since it was not present at the higher dose (group F).
对34只犬进行分组，获得次最大组胺剂量-反应曲线，这些犬被分为6组。这些组分别是：A组（n = 6）未治疗；B组（n = 6）给予阿托品（1 mg/kg）后；C组（n = 5）吸入维拉帕米（总剂量10 mg）后；D组（n = 5）吸入维拉帕米（总剂量100 mg）后；E组和F组（n = 6）与C组和D组相同，但预先给予阿托品（1 mg/kg）。在吸入组胺的递送浓度增加时，测量每组的总肺阻力（R1），并表示为基线瓣膜的比值。为每组获得复合平均曲线，并比较各组的最大记录反应（平均最大阻力比值）。似乎吸入维拉帕米（低剂量）和阿托品的组合降低了阿托品引起明显支气管收缩的抗胆碱能作用。这个意外结果取决于维拉帕米的剂量，因为在较高剂量组（F组）中不存在这种情况。
