用L-同型半胱氨酸处理后小鼠脑内S-腺苷-L-同型半胱氨酸的体内升高。

In vivo elevation of mouse brain S-adenosyl-L-homocysteine after treatment with L-homocysteine.

作者信息

Gharib A, Chabannes B, Sarda N, Pachéco H

出版信息

J Neurochem. 1983 Apr;40(4):1110-2. doi: 10.1111/j.1471-4159.1983.tb08100.x.

DOI:10.1111/j.1471-4159.1983.tb08100.x

Abstract

Intraperitoneal coadministration of adenosine and L-homocysteine markedly increased S-adenosyl-L-homocysteine in whole mouse brain, but further investigations showed that this elevation could also be produced following administration of L-homocysteine alone. The noted increase was maximal (+1325%) 10 min after treatment, remaining at about this level for 30-40 min before returning to control values after 180 min. Cerebral adenosine levels were decreased after treatment with L-homocysteine, adenosine, or these two substances in combination.

摘要

腹腔内联合给予腺苷和L-同型半胱氨酸可显著提高全脑S-腺苷-L-同型半胱氨酸水平，但进一步研究表明，单独给予L-同型半胱氨酸也可产生这种升高。这种升高在治疗后10分钟达到最大值（+1325%），在30-40分钟内保持在该水平左右，180分钟后恢复到对照值。用L-同型半胱氨酸、腺苷或这两种物质联合处理后，脑内腺苷水平降低。

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