大鼠脑中[14C]8-S-腺苷-L-高半胱氨酸的放射自显影定位

Autoradiographic localization of [14C]8-S-adenosyl-L-homocysteine in rat brain.

作者信息

Gharib A, Sarda N, Bobillier P, Pacheco H

出版信息

Neurosci Lett. 1984 Feb 10;44(2):205-9. doi: 10.1016/0304-3940(84)90082-x.

DOI:10.1016/0304-3940(84)90082-x

Abstract

Following intracarotid injection of [14C]8-S-adenosyl-L-homocysteine ( [14C]SAH) in the rat, radioactivity was localized by autoradiographic detection in the circumventricular organs, such as the pineal gland, choroid plexuses and area postrema, which lie outside the blood-brain barrier. HPLC analysis indicated a decrease of [14C]SAH radioactivity in these structures from 1 to 45 min, after injection. These results are discussed and related to the known pharmacological properties of SAH.

摘要

在大鼠颈内注射[14C]8-S-腺苷-L-高半胱氨酸（[14C]SAH）后，通过放射自显影检测将放射性定位在位于血脑屏障之外的室周器官，如松果体、脉络丛和最后区。高效液相色谱分析表明，注射后1至45分钟，这些结构中[14C]SAH的放射性降低。对这些结果进行了讨论，并与SAH已知的药理特性相关联。

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