Datta S C, Mukherjee K L
J Neurochem. 1983 Apr;40(4):1150-4. doi: 10.1111/j.1471-4159.1983.tb08106.x.
The levels of free amino acids were determined in human foetal brain regions during prenatal development. Variation in the distribution of amino acids and their rate of change in five segments of the CNS at different stages of ontogeny was observed. Striking developmental changes were found in the levels of aspartic acid in medulla-pons and spinal cord, glycine in the spinal cord, gamma-aminobutyric acid in the cerebral cortex, glutamic acid in the cerebral cortex, midbrain, and spinal cord, and taurine in the medulla-pons and spinal cord. At a late gestational period, glutamic acid was found most abundantly over all the brain regions, whereas the level of taurine was highest at an early gestational stage but not in spinal cord.
在产前发育过程中测定了人类胎儿脑区游离氨基酸的水平。观察到在个体发育的不同阶段，中枢神经系统五个节段中氨基酸分布的变化及其变化速率。在延髓-脑桥和脊髓中的天冬氨酸水平、脊髓中的甘氨酸水平、大脑皮层中的γ-氨基丁酸水平、大脑皮层、中脑和脊髓中的谷氨酸水平以及延髓-脑桥和脊髓中的牛磺酸水平均发现了显著的发育变化。在妊娠后期，谷氨酸在所有脑区中含量最为丰富，而牛磺酸水平在妊娠早期最高，但在脊髓中并非如此。
