Baker E L, Feldman R G, White R F, Harley J P, Dinse G E, Berkey C S
J Occup Med. 1983 Feb;25(2):125-30.
To facilitate the early detection of neurotoxicity in workers exposed to hazardous substances, we assembled a set of noninvasive neurobehavioral tests designed to assess memory, verbal concept formation, visuomotor performance, and mood. The tests were administered to an unexposed reference population and multivariate prediction equations were developed to control for effects of age, gender, and education. To define the briefest test set with appropriate sensitivity and specificity, we applied factor analysis and stepwise logistic regression to data from our referents and a group of lead-exposed workers. As a result, we have identified a comprehensive set of tests that can be administered in less than 40 minutes by trained medical technicians on plant premises and used to detect the early effects of neurotoxic substances on exposed workers. Guidelines for applying this technique to common work-place exposures, including other metals and organic solvents, are discussed.
为便于早期发现接触有害物质工人的神经毒性，我们汇集了一套非侵入性神经行为测试，旨在评估记忆、语言概念形成、视觉运动表现和情绪。对未接触有害物质的参照人群进行了这些测试，并建立了多变量预测方程，以控制年龄、性别和教育程度的影响。为确定具有适当敏感性和特异性的最短测试集，我们对来自参照人群和一组铅接触工人的数据进行了因子分析和逐步逻辑回归。结果，我们确定了一套全面的测试，经过培训的医学技术人员可在工厂场地用不到40分钟的时间进行测试，并用于检测神经毒性物质对接触工人的早期影响。文中还讨论了将该技术应用于常见工作场所接触情况（包括其他金属和有机溶剂）的指南。
