Kurosu Y, Saegusa Y, Tominaga M, Morita K
Jpn J Clin Oncol. 1983 Mar;13(1):25-30.
The in vitro blastogenic responses of peripheral blood lymphocytes (PBL) and the regional lymph node lymphocytes (LNL) from cancer patients to autochthonous tumor cells (TC) were investigated. A positive lymphocyte response to autochthonous TC was observed in 23% (6/26) for PBL and 34% (9/26) for LNL. There seemed to be an inverse relationship between PBL and LNL responses to autochthonous TC. There was no significant difference between PBL and LNL responses to autochthonous TC according to the primary site of the tumor. Analysis of PBL and LNL responses to autochthonous TC according to the extent of the disease revealed that LNL were definitely more reactive than PBL in patients with a primary tumor that had not spread to the regional lymph nodes.
研究了癌症患者外周血淋巴细胞（PBL）和区域淋巴结淋巴细胞（LNL）对自身肿瘤细胞（TC）的体外增殖反应。PBL对自身TC的阳性淋巴细胞反应在23%（6/26）的患者中观察到，LNL为34%（9/26）。PBL和LNL对自身TC的反应之间似乎存在反比关系。根据肿瘤的原发部位，PBL和LNL对自身TC的反应没有显著差异。根据疾病程度分析PBL和LNL对自身TC的反应发现，在原发性肿瘤尚未扩散到区域淋巴结的患者中，LNL的反应肯定比PBL更活跃。
