结直肠癌中淋巴细胞对同种异体白细胞和自体肿瘤细胞的增殖反应。

Lymphocyte blastogenic responses to allogeneic leukocytes and autochthonous tumor cells in colorectal carcinoma.

作者信息

Jubert A V, Talbott T M, Mazier W P, MacKeigan J M, Campos M M, Muldoon J P, Benjamin H E, Ferguson J A, Bowman H E

出版信息

J Surg Oncol. 1977;9(2):171-8. doi: 10.1002/jso.2930090211.

Abstract

The blastogenic reactivity of peripheral blood lymphocytes (PBL) and mesenteric lymph node lymphocytes (LNL) against normal allogeneic leukocytes and autochthonous colorectal carcinoma cells is evaluated in 36 patients, and correlated with the patient's Dukes classification. Mesenteric LNL react significantly better than PBL to allogeneic leukocytes in both Dukes B and C (p less than 0.05). There are too few patients in Dukes A and D to permit statistical evaluation but the trend is the same. By contrast, LNL fail to react to autochthonous tumor cells in all classes, except in a few Dukes B patients. The proportion of PBL reactivity to autochthonous tumor cells seems to increase for Dukes C and D. It is possible that specific lymphocyte reactivity in colorectal carcinoma may be related to the antigenicity and immunogenicity of the tumor.

摘要

对36例患者外周血淋巴细胞（PBL）和肠系膜淋巴结淋巴细胞（LNL）针对正常同种异体白细胞及自身结肠癌细胞的增殖反应性进行了评估，并与患者的Dukes分期相关联。在Dukes B期和C期，肠系膜LNL对同种异体白细胞的反应明显优于PBL（p<0.05）。Dukes A期和D期患者数量过少，无法进行统计学评估，但趋势相同。相比之下，除少数Dukes B期患者外，所有分期的LNL对自身肿瘤细胞均无反应。Dukes C期和D期患者中，PBL对自身肿瘤细胞的反应比例似乎有所增加。结直肠癌中特异性淋巴细胞反应性可能与肿瘤的抗原性和免疫原性有关。