Midiri G, Amanti C, Consorti F, Benedetti M, Del Buono S, Di Tondo U, Castagna G, Peronace L, Di Paola M
J Surg Oncol. 1983 Apr;22(4):257-60. doi: 10.1002/jso.2930220410.
In order to demonstrate a prognostic value of preoperative CEA levels, we have tried to define a correlation between CEA and histologic stage of tumor in 124 patients with colorectal carcinoma. CEA concentration has been evaluated by radioimmunologic assay and the histologic stage following Dukes' classification. The results show a 25.0% positivity rate for patients in stage A, 48.2% for stage B, 61.1% for stage C, and 85.7% for stage D. The mean CEA values are 7.8 ng/ml in the first group, 30.3 ng/ml in the second, 58.1 ng/ml in the third, and 134.3 ng/ml in the last group. Furthermore, we have tried to relate the histopathologic grade of the tumor (G) with CEA levels in 54 patients of the 124. We conclude that preoperative CEA has a prognostic value, and it is useful in the staging of colorectal cancer patients. A low concentration indicates an early stage of the tumor, while a high concentration indicates a wide spread of disease; on the other hand, there are not significant correlations with cancer grading.
为了证明术前癌胚抗原（CEA）水平的预后价值，我们试图在124例结直肠癌患者中确定CEA与肿瘤组织学分期之间的相关性。通过放射免疫测定评估CEA浓度，并根据Dukes分类确定组织学分期。结果显示，A期患者的阳性率为25.0%，B期为48.2%，C期为61.1%，D期为85.7%。第一组的平均CEA值为7.8 ng/ml，第二组为30.3 ng/ml，第三组为58.1 ng/ml，最后一组为134.3 ng/ml。此外，我们还在124例患者中的54例中尝试将肿瘤的组织病理学分级（G）与CEA水平相关联。我们得出结论，术前CEA具有预后价值，并且对结直肠癌患者的分期有用。低浓度表明肿瘤处于早期，而高浓度表明疾病广泛扩散；另一方面，与癌症分级没有显著相关性。
