Theodorakis M E, Zamkoff K W, Davey F R, Ginsberg S J, Cass D L, Gottlieb A J
Med Pediatr Oncol. 1983;11(1):20-6. doi: 10.1002/mpo.2950110105.
A 52-year-old female presented with Philadelphia chromosome-positive acute nonlymphocytic leukemia and a morphologically benign-appearing histiocytosis with intramedullary cytophagocytosis of formed blood elements. No cause of the reactive histiocytosis could be found. Despite initial successful therapy of the acute nonlymphocytic leukemia with induction of a cytological remission, pancytopenia with marked cytophagocytosis persisted. Therapy aimed at reducing the degree of cytophagocytosis by the histiocytes, in the form of vinblastine-treated platelets and, subsequently, prednisone, was instituted. There was no significant clinical response to either therapeutic maneuver. Cytophagocytosis persisted until leukemic relapse and death ensued.
一名52岁女性，患有费城染色体阳性的急性非淋巴细胞白血病，同时伴有形态学上看似良性的组织细胞增多症，骨髓内存在成熟血细胞的噬血细胞现象。未发现反应性组织细胞增多症的病因。尽管最初对急性非淋巴细胞白血病进行了成功治疗，诱导了细胞学缓解，但全血细胞减少伴明显噬血细胞现象仍持续存在。采取了通过长春碱处理的血小板以及随后的泼尼松来减少组织细胞噬血程度的治疗方法。两种治疗手段均未产生显著临床反应。噬血细胞现象一直持续到白血病复发并导致死亡。
