Shafer D A, Falek A, Madden J J, Tadayon F, Pline M, Bokos P J, Kuehnle J C, Mendelson J
Mutat Res. 1983 Apr;109(1):73-82. doi: 10.1016/0027-5107(83)90096-9.
The SCE base level frequency and SCE levels induced by far-UV (254 nm) treatment of cells in early G1 and early S phases of the cell cycle were significantly higher in leukocytes from heroin addicts as compared to controls. The increased SCE levels in addicts was greatest at base level and smallest after UV irradiation of cells in S phase. These results corroborate and extend our previous findings of increased chromosome damage and reduced DNA-repair synthesis in heroin users. Since opiates do not directly damage DNA, the elevated cytogenetic effects associated with opiate use probably arise from secondary promotional effects related to opiate-mediated alterations in leukocyte metabolism.
与对照组相比，海洛因成瘾者白细胞中姐妹染色单体互换（SCE）的基础水平频率以及在细胞周期的G1早期和S早期用远紫外线（254纳米）处理细胞所诱导的SCE水平显著更高。成瘾者中SCE水平的增加在基础水平时最大，而在S期细胞接受紫外线照射后最小。这些结果证实并扩展了我们之前关于海洛因使用者染色体损伤增加和DNA修复合成减少的发现。由于阿片类药物不会直接损伤DNA，与使用阿片类药物相关的细胞遗传学效应升高可能源于与阿片类药物介导的白细胞代谢改变相关的继发性促进作用。
