Vassiliades N, Mourelatos D, Dozi-Vassiliades J, Epivatianos P, Hatzitheodoridou P
Mutat Res. 1986 Jun;170(3):125-7. doi: 10.1016/0165-1218(86)90025-x.
The aim of this study was to determine the frequency of sister-chromatid exchanges (SCEs) in heroin-cannabis, heroin and cannabis addicts. The group of 84 subjects consisted of 42 controls, 16 heroin-cannabis addicts, 12 heroin addicts and 14 cannabis addicts. The mean number of SCEs/cell was 12.95 in heroin-cannabis addicts, 12.05 in heroin addicts and 11.99 in cannabis addicts. These values are significantly (P less than 0.002) higher than the mean values found in controls. This increase in SCEs may be related to reduced DNA repair in chronic drug addicts, which would allow the fixation or retention of a greater fraction of the DNA lesions caused by normal environmental exposure.
本研究的目的是确定海洛因-大麻成瘾者、海洛因成瘾者和大麻成瘾者中姐妹染色单体交换（SCEs）的频率。84名受试者组成的群体包括42名对照组、16名海洛因-大麻成瘾者、12名海洛因成瘾者和14名大麻成瘾者。海洛因-大麻成瘾者的平均SCEs/细胞数为12.95，海洛因成瘾者为12.05，大麻成瘾者为11.99。这些值显著高于对照组（P小于0.002）。SCEs的这种增加可能与慢性吸毒者DNA修复减少有关，这会使由正常环境暴露引起的更大比例的DNA损伤得以固定或保留。
