Hansmann I, Jenderny J, Probeck H D
Mutat Res. 1983 Apr;109(1):99-110. doi: 10.1016/0027-5107(83)90099-4.
Females from the NMRI/Han mouse strain ovulate a high number of diploid oocytes (about 12%) after gonadotrophin-stimulated ovulation. These oocytes can be fertilized and develop into triploid embryos subsequently. The exposure of such gonadotrophin-primed females to X-ray doses of 0.05, 0.10, 0.20 or 0.40 Gy during the preovulatory period (2 h after the HCG dose) significantly decreased the percentage of diploid oocytes. After the highest dose used, i.e. 0.80 Gy, however, the incidence was on the level from unirradiated females, again. We suggest that the observed negative hump-shaped dose response of diploidy is not caused by secondary modifications induced by irradiation, such as a selective killing of diploid oocytes before ovulation, or a (compensatory) super-ovulation of only normal oocytes, but rather is caused by a direct radiobiological interference of low doses in protecting from gonadotrophin-induced aneuploidy.
NMRI/Han小鼠品系的雌性小鼠在促性腺激素刺激排卵后会排出大量二倍体卵母细胞（约12%）。这些卵母细胞能够受精，并随后发育成三倍体胚胎。在排卵前期（注射人绒毛膜促性腺激素剂量后2小时），将此类经促性腺激素预处理的雌性小鼠暴露于0.05、0.10、0.20或0.40 Gy的X射线剂量下，会显著降低二倍体卵母细胞的百分比。然而，在使用最高剂量即0.80 Gy后，发生率又恢复到未受辐照雌性小鼠的水平。我们认为，观察到的二倍体的负驼峰形剂量反应并非由辐射诱导的二次修饰引起，例如排卵前对二倍体卵母细胞的选择性杀伤，或仅正常卵母细胞的（代偿性）超排卵，而是由低剂量的直接放射生物学干扰导致，这种干扰可防止促性腺激素诱导的非整倍体形成。
