Pellestor F, Sèle B
Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, La Tronche, France.
Am J Hum Genet. 1988 Feb;42(2):274-83.
The karyotype was determined for 201 unfertilized human oocytes recovered from 87 women participating in an in vitro fertilization program. Their mean age was 30.6 years (range 22-40 years). Thirteen oocytes did not exhibit the first polar body and were found to be in the first-metaphase stage. The remaining 188 eggs were assessed as mature and classified into two groups according to the supposed origin of fertilization failure. The overall incidence of aneuploidy was 18.6%. This rate was higher in the group of unexplained fertilization failure (22.5%) than in the group of fertilization failure due to sperm deficiency (10.2%). This may reflect a relationship between the genomic constitution of the oocyte and its fertilizability. On the other hand, no increase of aneuploidy was observed with maternal aging.
对从87名参与体外受精项目的女性中回收的201枚未受精的人类卵母细胞进行了核型分析。她们的平均年龄为30.6岁（范围为22 - 40岁）。13枚卵母细胞未显示出第一极体，被发现处于第一次中期阶段。其余188枚卵子被评估为成熟，并根据推测的受精失败原因分为两组。非整倍体的总体发生率为18.6%。这一比率在不明原因受精失败组（22.5%）中高于精子缺乏导致的受精失败组（10.2%）。这可能反映了卵母细胞的基因组构成与其受精能力之间的关系。另一方面，未观察到随着母亲年龄增长非整倍体增加。
