Lindner A
Nephron. 1983;33(2):121-6. doi: 10.1159/000182925.
This paper describes our initial clinical findings in a small group of patients with acute oliguric renal failure, who were resistant to extracellular volume expansion and furosemide in large doses. Based on our experience in an experimental model of acute renal failure in the dog, we administered a combination of low-dose dopamine (1-3 micrograms/kg/min i.v.) and furosemide (100-200 mg every 6-8 h). This combination was uniformly effective in inducing a brisk, lasting diuresis and was associated with either stable or reduced serum creatinine levels in two-thirds of the patients. No toxicity was found. These findings would warrant extensive study of this drug combination in a larger, well-controlled, randomized group with oliguric renal failure.
本文描述了我们对一小群急性少尿性肾衰竭患者的初步临床研究结果，这些患者对细胞外液扩容和大剂量速尿均无反应。基于我们在犬急性肾衰竭实验模型中的经验，我们给予了小剂量多巴胺（静脉注射1 - 3微克/千克/分钟）和速尿（每6 - 8小时100 - 200毫克）的联合治疗。这种联合治疗在诱导快速、持久的利尿方面均有效，并且在三分之二的患者中血清肌酐水平保持稳定或下降。未发现毒性反应。这些发现值得在更大规模、严格对照的随机分组少尿性肾衰竭患者群体中对这种药物组合进行广泛研究。
