运动替代试验作为检测大鼠新药麻醉特性工具的进一步证据。

Further evidence for a motility substitution test as a tool to detect the narcotic character of new drugs in rats.

作者信息

Bartoletti M, Gaiardi M, Gubellini C, Babbini M

出版信息

Neuropharmacology. 1983 Feb;22(2):177-81. doi: 10.1016/0028-3908(83)90006-0.

Abstract

Time effects of three doses of codeine, d-propoxyphene, meperidine and dextromethorphan upon locomotor activity have been investigated in naive rats as well as in animals treated chronically with 20 mg/kg of morphine daily. The first three drugs exhibited a motility pattern qualitatively similar to that of morphine; in chronically-treated rats cross-tolerance occurred to acute depressant effects and cross-sensitization to acute excitatory effects. In the case of meperidine however cross-sensitization appeared to be small. Dextromethorphan presented effects similar to morphine only in a very large dose. The present data, together with those of previous work, demonstrate that a locomotor activity substitution test may predict the morphine-like addictive properties of a drug.

摘要

已在未接触过药物的大鼠以及每天用20毫克/千克吗啡长期处理的动物中研究了三种剂量的可待因、右丙氧芬、哌替啶和右美沙芬对运动活性的时间效应。前三种药物表现出与吗啡在性质上相似的运动模式；在长期处理的大鼠中，对急性抑制作用出现交叉耐受性，对急性兴奋作用出现交叉敏感性。然而，就哌替啶而言，交叉敏感性似乎较小。右美沙芬仅在非常大的剂量下才表现出与吗啡相似的作用。目前的数据以及先前研究的数据表明，运动活性替代试验可以预测一种药物的类吗啡成瘾特性。