Guerrera G, Melina D, Cocco F
Minerva Med. 1983 Mar 17;74(11):525-30.
Hyperuricaemia was encountered in 29% of 55 subjects with essential hypertension, who had not been treated with anti-hypertensive drugs, as against a 10% incidence in a group with normal blood pressure. No relationship between hyperuricaemia and level of hypertension was found. The normal glomerular filtration, the frequent reduction in uric acid clearance and its correlation with uricaemia are held to be indicative of a tubular defect in the excretion of uric acid, as a cause of hyperuricaemia. The reduction in renal plasma flow and its significant correlation with uricaemia and uric acid clearance are considered probable causes of reduced renal excretion. In conclusion it is hypothesised that hypertension triggers renal haemodynamic disturbances and hence hyperuricaemia.
在55名未接受过抗高血压药物治疗的原发性高血压患者中，29%出现高尿酸血症，而血压正常组的发生率为10%。未发现高尿酸血症与高血压水平之间存在关联。肾小球滤过正常、尿酸清除率频繁降低及其与尿酸血症的相关性被认为表明尿酸排泄存在肾小管缺陷，这是高尿酸血症的一个原因。肾血浆流量减少及其与尿酸血症和尿酸清除率的显著相关性被认为是肾脏排泄减少的可能原因。总之，据推测高血压引发肾脏血液动力学紊乱，进而导致高尿酸血症。
