Mirahmadi M K, Byrne C, Barton C, Penera N, Gordon S, Vaziri N D
Paraplegia. 1983 Feb;21(1):23-9. doi: 10.1038/sc.1983.4.
Measured endogenous creatinine clearance (Ccr) was compared with the predicted Ccr in 22 paraplegic, 36 tetraplegic and 11 ambulatory male individuals as well as 11 ambulatory females all of whom had normal renal function. While the predicted and measured values closely matched in the ambulatory patients the predicted values in the spinal cord injured patients consistently exceeded the measured values. It thus appears that the original Cockcroft and Gault formula; (formula; see text) when applied to SCI patients can be misleading. Modification of the original formula using a correction factor of 0.8 in paraplegics and 0.6 in tetraplegics was found to allow prediction of Ccr from age, sex, body weight, and serum creatinine in these patients with reasonable accuracy.
对22名截瘫男性、36名四肢瘫男性、11名能自主行走的男性个体以及11名能自主行走且肾功能正常的女性个体，将测得的内生肌酐清除率（Ccr）与预测的Ccr进行比较。虽然在能自主行走的患者中，预测值与测量值密切匹配，但脊髓损伤患者的预测值始终超过测量值。因此，最初的Cockcroft和Gault公式（公式；见正文）应用于脊髓损伤患者时可能会产生误导。发现对原始公式进行修改，截瘫患者使用校正系数0.8，四肢瘫患者使用校正系数0.6，能够在这些患者中根据年龄、性别、体重和血清肌酐合理准确地预测Ccr。
