Dawood M Y, Wang C F, Gupta R, Fuchs F
Obstet Gynecol. 1978 Aug;52(2):205-9.
Fetal oxytocin contribution to the mother during spontaneous labor was investigated using a specific and sensitive radioimmunoassay to measure oxytocin in blood, amniotic fluid, and urine. In 26 subjects with spontaneous labor and vaginal delivery (Group I) and 18 subjects with cesarean section after labor (Group II), umbilical arterial plasma (UA) oxytocin concentrations were significantly higher than umbilical venous plasma (UV) ocytocin concentrations. With elective cesarean section (Group III), UA oxytocin concentration was 29.8 +/- 7.5 pg/ml and UV oxytocin concentration was 16.1 +/- 5.9 pg/ml (n = 14). In contrast, the mean UV oxytocin concentration was higher than the mean UA oxytocin concentration, when oxytocin was given to the mothen concentration in Groups I and II was significantly higher than in Group III. Amniotic fluid oxytocin concentrations in Group I and II patients were higher than in Group III. Oxytocin was also present in fetal urine. The findings indicate that during spontaneous labor, oxytocin is produced by the fetus and flows toward the maternal circulation.
采用特异性灵敏放射免疫分析法测定血液、羊水和尿液中的催产素，对自然分娩过程中胎儿催产素对母体的作用进行了研究。在26例自然分娩并经阴道分娩的受试者（第一组）和18例分娩后行剖宫产的受试者（第二组）中，脐动脉血浆（UA）催产素浓度显著高于脐静脉血浆（UV）催产素浓度。在择期剖宫产的受试者（第三组）中，UA催产素浓度为29.8±7.5 pg/ml，UV催产素浓度为16.1±5.9 pg/ml（n = 14）。相反，当给母亲使用催产素时，第一组和第二组的UV催产素平均浓度高于UA催产素平均浓度，且第一组和第二组的浓度显著高于第三组。第一组和第二组患者的羊水催产素浓度高于第三组。胎儿尿液中也存在催产素。研究结果表明，在自然分娩过程中，胎儿产生催产素并流向母体循环。
