丙酮对1,1 - 二氯乙烯毒性的剂量依赖性修饰作用。

Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.

作者信息

Hewitt W R, Plaa G L

出版信息

Toxicol Lett. 1983 Apr;16(1-2):145-52. doi: 10.1016/0378-4274(83)90023-1.

Abstract

The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene (DCE) in male rats was investigated. A biphasic potentiation of DCE-induced hepatotoxicity was observed; low doses (5 and 10 mmol/kg, p.o.) of acetone were active, whereas higher doses (15 and 30 mmol/kg) were not. Nephrotoxicity was not affected.

摘要

研究了丙酮增强雄性大鼠中1,1-二氯乙烯（DCE）毒性的能力。观察到DCE诱导的肝毒性呈双相增强；低剂量（5和10 mmol/kg，口服）的丙酮具有活性，而高剂量（15和30 mmol/kg）则无活性。肾毒性未受影响。