镉蓄积大鼠肝脏和肾脏中金属硫蛋白的死后及体外二聚化
Post-mortem and in vitro dimerization of metallothionein in cadmium-accumulated rat liver and kidney.
作者信息
Suzuki K T, Ohnuki R, Yaguchi K
出版信息
Toxicol Lett. 1983 Apr;16(1-2):77-84. doi: 10.1016/0378-4274(83)90013-9.
PMID:6836617
Abstract
Metallothionein (MT) in the livers and kidneys of rats that died after repeated injections of cadmium (Cd) was selectively oxidized to dimers of MT with time after death. In vitro experiments suggest that the dimer formation is facilitated in heavily Cd-accumulated tissues by oxygen and temperature when cell damage occurs.
摘要
在反复注射镉（Cd）后死亡的大鼠肝脏和肾脏中的金属硫蛋白（MT），在死后随时间会选择性地氧化为MT二聚体。体外实验表明，当细胞发生损伤时，在镉大量蓄积的组织中，氧气和温度会促进二聚体的形成。
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