大鼠肾金属硫蛋白中铜含量降低及其与急性镉肾病的关系。

Decreased copper content in rat kidney metallothionein and its relation to acute cadmium nephropathy.

作者信息

Suzuki K T, Yamamura M, Yamada Y K, Shimizu F

出版信息

Toxicol Lett. 1980 Dec;7(2):137-42. doi: 10.1016/0378-4274(80)90046-6.

Abstract

Repeated s.c. injections of cadmium chloride into rats (3 mg Cd/kg body weight, 4 times a week) caused acute and transitory tubular necrosis after 2 to 3 weeks; recovery was observed after 4 weeks despite continued loading. Kidney copper decreased for the first 3 weeks and was slightly increased after 4 weeks. Distribution profiles of cadmium (Cd), zinc (Zn), copper (Cu) on an SW column revealed that elution profiles of kidney metallothionein changed from typical kidney with high copper content to typical liver metallothioneins with tubular necrosis and restoration.

摘要

每周4次给大鼠皮下重复注射氯化镉（3毫克镉/千克体重），2至3周后会导致急性和短暂性肾小管坏死；尽管继续负荷给药，但4周后观察到恢复情况。肾脏铜含量在最初3周下降，4周后略有增加。在SW柱上镉（Cd）、锌（Zn）、铜（Cu）的分布图谱显示，肾脏金属硫蛋白的洗脱图谱从典型的高铜含量肾脏型转变为伴有肾小管坏死和恢复的典型肝脏金属硫蛋白型。