Guaitani A, Della Torre P, Morasca L, Pintus C, Bartosek I
Tumori. 1983 Feb 28;69(1):1-9. doi: 10.1177/030089168306900101.
Two sublines of Walker 256 carcinoma have been characterized for their ability to metastasize and to induce cachexia. The invasive, metastasizing line A induced terminal anorexia in rats with a mean survival time of 27 +/- 1.5 days. The non-invasive line B induced early anorexia and cachexia with a mean survival time of only 15 +/- 1 days. At death, the line B tumor was still smaller than the line A one, and no metastases were detectable. These two sublines are discussed as a composite model for studying anorexia and cachexia together with invasion and metastasis.
已对Walker 256癌的两个亚系进行了特征描述，以了解它们的转移能力和诱发恶病质的能力。侵袭性转移亚系A可诱发大鼠出现终末期厌食，平均存活时间为27±1.5天。非侵袭性亚系B诱发早期厌食和恶病质，平均存活时间仅为15±1天。死亡时，亚系B肿瘤仍小于亚系A肿瘤，且未检测到转移。这两个亚系被作为一个综合模型进行讨论，用于同时研究厌食、恶病质以及侵袭和转移。
