Guaitani A, Recchia M, Carli M, Rocchetti M, Bartosek I, Garattini S
Oncology. 1982;39(3):173-8. doi: 10.1159/000225631.
Data on anorexia and cachexia induced by Walker carcinoma 256 in Sprague-Dawley rats were analyzed in order to standardize an experimental model using a statistical (nondeterministical) procedure for assessing the efficacy of potential orexigenic agents. This model was characterized by a mean survival time of 14 +/- 1 days and by food intake and body weight loss starting from day 6 after tumor implantation. The complex course of cachexia was characterized by reduction in the weight of gastrocnemius muscle and epididymal adipose tissue, taken as representative sites of loss of proteins and lipids.
对沃克癌256诱导的斯普拉格-道利大鼠厌食和恶病质数据进行了分析，以便使用统计（非确定性）程序来标准化一种实验模型，以评估潜在促食欲剂的功效。该模型的特征是平均存活时间为14±1天，且从肿瘤植入后第6天开始出现食物摄入量和体重减轻。恶病质的复杂过程表现为腓肠肌和附睾脂肪组织重量减轻，这些被视为蛋白质和脂质流失的代表性部位。
