Muntean W
Wien Klin Wochenschr. 1983 Jan 7;95(1):1-5.
Newborns have low levels of the vitamin K dependent clotting factors. Early studies were suggestive of vitamin K deficiency. Recently these findings were questioned by studies that failed to detect signs of vitamin K deficiency in the clotting system of newborns using more specific methods, while other studies did find signs of vitamin K deficiency using the same methods. The question was finally solved by direct measurement of vitamin K showing very low levels of the vitamin in the serum of newborns immediately after birth. Whether vitamin K supplementation to the mother reduces the incidence of vitamin K induced changes in the clotting system of newborns remains to be elucidated. In the meantime it seems prudent to administer parenteral vitamin K prophylactically to all newborns immediately after birth.
新生儿体内维生素K依赖的凝血因子水平较低。早期研究提示存在维生素K缺乏。最近,一些研究对这些发现提出了质疑,这些研究使用更具体的方法未能在新生儿凝血系统中检测到维生素K缺乏的迹象,而其他研究使用相同方法却发现了维生素K缺乏的迹象。最终通过直接测量维生素K解决了这个问题,结果显示新生儿出生后血清中维生素K水平极低。母亲补充维生素K是否能降低新生儿凝血系统中维生素K诱导变化的发生率仍有待阐明。与此同时,在出生后立即对所有新生儿预防性注射维生素K似乎是谨慎之举。