Sen S, Hahmann H, Becker D, Rettig G, Schieffer H, Bette L
Z Kardiol. 1983 Jan;72(1):32-6.
To determine the incidence and significance of angina pectoris in aortic valve disease, clinical, haemodynamic, and angiographic data concerning 111 consecutive patients aged 27-68 years (mean 52) were retrospectively analysed. 14.4% (group A) had significant, 85.6% (group B) had no coronary heart disease. There was a significant difference between the groups regarding the incidence of typical angina pectoris (62.5% vs 31.6%, p less than 0.01) and freedom from chest pain (12.5% vs 32.6%, p less than 0.05). No difference, however, could be found concerning the incidence of atypical chest pain (25% vs 35.8%). Of 12 patients aged over 50 years with coronary artery disease, no patient was free of angina pectoris. 83% had typical, 17% had atypical angina pectoris. Of 4 patients below 45 years with coronary artery disease, however, none had typical angina pectoris, 2 patients had atypical angina, and 2 patients had none. These results demonstrate that typical angina pectoris in patients with aortic valve disease is not a specific indicator of concomitant significant coronary artery disease. On the other hand, absence of chest pain does not predict absence of coronary artery disease, especially in younger patients. We therefore suggest that coronary angiography be carried out in all adult patients in whom aortic valve surgery is being considered.
为了确定主动脉瓣疾病中心绞痛的发生率及意义,我们对111例年龄在27至68岁(平均52岁)的连续患者的临床、血流动力学和血管造影数据进行了回顾性分析。14.4%(A组)患有严重冠心病,85.6%(B组)无冠心病。两组在典型心绞痛发生率(62.5%对31.6%,p<0.01)和无胸痛发生率(12.5%对32.6%,p<0.05)方面存在显著差异。然而,非典型胸痛发生率(25%对35.8%)无差异。在12例年龄超过50岁的冠心病患者中,无一例无心绞痛。83%有典型心绞痛,17%有非典型心绞痛。然而,在4例年龄低于45岁的冠心病患者中,无一例有典型心绞痛,2例有非典型心绞痛,2例无胸痛。这些结果表明,主动脉瓣疾病患者的典型心绞痛并非合并严重冠状动脉疾病的特异性指标。另一方面,无胸痛并不能预测无冠状动脉疾病,尤其是在年轻患者中。因此,我们建议对所有考虑进行主动脉瓣手术的成年患者进行冠状动脉造影。