Hinds W, First M W, Huber G L, Shea J W
Am Ind Hyg Assoc J. 1983 Feb;44(2):113-8. doi: 10.1080/15298668391404473.
An understanding of the factors influencing respiratory deposition of cigarette smoke in smokers is needed to accurately control this important source of respiratory exposure in epidemiological studies of workers. Only a few studies have characterized the deposition of cigarette smoke in smokers and these involve methods that interfere with normal smoking. A technique for measuring puff volume, inhaled amount, and respiratory deposition of cigarette smoke particulate phase has been developed. It provides satisfactory accuracy (+/- 10%) and causes minimal disruption of normal smoking pattern. The technique captures exhaled smoke with an exhaust hood and establishes the amount of inhaled smoke by monitoring puff volume, puff duration, and puff timing and replaying the exact smoking sequence with matched cigarettes. Mass of captured cigarette smoke is evaluated by fluorophotometry. Preliminary trials with 11 paid volunteers gave an average puff volume of 53 mL and smoke deposition ranged from 22% to 75% with an average of 47%. Measured depositions are lower than previously published values and higher than would be predicted for submicrometer sized particles during normal breathing.
为了在工人的流行病学研究中准确控制这一重要的呼吸道暴露源，需要了解影响吸烟者呼吸道中香烟烟雾沉积的因素。只有少数研究对吸烟者呼吸道中香烟烟雾的沉积进行了表征，且这些研究涉及干扰正常吸烟的方法。现已开发出一种测量香烟烟雾颗粒相的 puff 体积、吸入量和呼吸道沉积的技术。该技术具有令人满意的准确度（±10%），并且对正常吸烟模式的干扰最小。该技术通过排气罩捕获呼出的烟雾，并通过监测 puff 体积、puff 持续时间和 puff 时间，以及用匹配的香烟重现精确的吸烟顺序来确定吸入烟雾的量。捕获的香烟烟雾质量通过荧光光度法进行评估。对 11 名有偿志愿者进行的初步试验得出，平均 puff 体积为 53 mL，烟雾沉积范围为 22%至 75%，平均为 47%。测量的沉积量低于先前公布的值，但高于正常呼吸时亚微米级颗粒的预测值。
