German L D, Gallagher J J, Broughton A, Guarnieri T, Trantham J L
Am J Cardiol. 1983 Apr;51(7):1203-6. doi: 10.1016/0002-9149(83)90369-7.
The effects of exercise and isoproterenol on atrial fibrillation (AF) were studied in 17 patients with Wolff-Parkinson-White syndrome (WPW) to assess the risk of developing a rapid ventricular response. Mean cycle length (R-R interval) and shortest R-R interval between both preexcited and nonpreexcited QRS complexes were recorded, as well as the percentage of preexcited complexes during control periods, during bicycle exercise, and during isoproterenol infusion. Exercise resulted in significantly shorter mean cycle length and the shortest R-R interval between nonpreexcited complexes. Exercise also resulted in a significantly lower percentage of preexcited complexes during AF, but had no effect on the R-R intervals between preexcited complexes. Isoproterenol had a variable effect on the percentage of preexcited QRS complexes, but resulted in significant shortening of mean cycle length and the shortest R-R interval between both normal and preexcited complexes. With isoproterenol, 12 of 17 patients had shortest preexcited R-R intervals less than or equal to 215 ms, compared with 6 of 17 in the control state. Isoproterenol infusion increased the rate of conduction over the accessory pathway during AF and allowed better assessment of the risk of excessively rapid rates occurring during AF. Exercise is not an adequate test for this purpose.
对17例预激综合征（WPW）患者研究了运动和异丙肾上腺素对心房颤动（AF）的影响，以评估发生快速心室反应的风险。记录了预激和非预激QRS波群之间的平均周期长度（R-R间期）和最短R-R间期，以及在对照期、自行车运动期间和异丙肾上腺素输注期间预激波群的百分比。运动导致平均周期长度显著缩短，非预激波群之间的最短R-R间期缩短。运动还导致房颤期间预激波群的百分比显著降低，但对预激波群之间的R-R间期没有影响。异丙肾上腺素对预激QRS波群的百分比有不同影响，但导致平均周期长度显著缩短，正常和预激波群之间的最短R-R间期缩短。使用异丙肾上腺素时，17例患者中有12例预激R-R间期最短小于或等于215毫秒，而对照状态下17例中有6例。异丙肾上腺素输注增加了房颤期间经旁路传导的速率，并能更好地评估房颤期间发生过速的风险。为此目的，运动不是一项充分的检查。
