补充抗坏血酸对青年男性铜状态的影响。

Influence of ascorbic acid supplementation on copper status in young adult men.

作者信息

Finley E B, Cerklewski F L

出版信息

Am J Clin Nutr. 1983 Apr;37(4):553-6. doi: 10.1093/ajcn/37.4.553.

DOI:10.1093/ajcn/37.4.553

Abstract

The influence of ascorbic acid supplementation on the copper status of young adult men was investigated. Subjects consuming self-selected diets took 500 mg of ascorbic acid with each meal (1500 mg/day) for 64 days. Blood samples were obtained at 0, 28, 52, and 64 days in order to determine serum copper and serum ceruloplasmin. Each subject thus served as his own control. Analyses were repeated 20 days after the ascorbic acid supplement was terminated. Serum ceruloplasmin activity was significantly reduced (p less than 0.01) at every data point throughout the ascorbic acid supplementation period. A similar but nonsignificant trend was observed for serum copper. Furthermore there was a significant increase (p less than 0.01) in serum copper concentration 20 days after the supplementation period. Although observed effects occurred within physiological ranges of normal values, this study confirms that a high ascorbic acid intake is antagonistic to copper status of men as has been demonstrated in laboratory animals.

摘要

研究了补充抗坏血酸对青年男性铜状态的影响。食用自选饮食的受试者每餐服用500毫克抗坏血酸（1500毫克/天），持续64天。在第0、28、52和64天采集血样，以测定血清铜和血清铜蓝蛋白。因此，每个受试者都作为自己的对照。在抗坏血酸补充剂停用20天后重复进行分析。在整个抗坏血酸补充期间的每个数据点，血清铜蓝蛋白活性均显著降低（p<0.01）。血清铜也观察到类似但不显著的趋势。此外，补充期结束20天后，血清铜浓度显著升高（p<0.01）。尽管观察到的效应发生在正常值的生理范围内，但本研究证实，高抗坏血酸摄入量对男性铜状态具有拮抗作用，这已在实验动物中得到证实。