原发性血小板增多症：一种造血干细胞的克隆性疾病。
Essential thrombocythemia: a clonal disorder of hematopoietic stem cell.
作者信息
Singal U, Prasad A S, Halton D M, Bishop C
出版信息
Am J Hematol. 1983 Apr;14(2):193-6. doi: 10.1002/ajh.2830140212.
PMID:6837574
Abstract
We studied 5 patients with essential thrombocythemia utilizing glucose-6-phosphate dehydrogenase (G-6-PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.
摘要
我们利用葡萄糖-6-磷酸脱氢酶（G-6-PD）作为细胞标志物来确定克隆性，对5例原发性血小板增多症患者进行了研究。其中1例患者在成纤维细胞等非造血组织中，其同工酶B和A为杂合子，但在红细胞、中性粒细胞和血小板中仅表现为同工酶B型。我们的研究支持这样一种观点，即原发性血小板增多症是一种起源于多能干细胞的克隆性疾病。
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