Gaetani G F, Ferraris A M, Galiano S, Giuntini P, Canepa L, d'Urso M
Blood. 1982 Jan;59(1):76-9.
A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (GdB/GdMed), was investigated to test for the clonal origin of this myeloproliferative disorder. In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes.
一名原发性血小板增多症患者，其葡萄糖-6-磷酸脱氢酶缺乏症（GdB/GdMed）为杂合子，为检测这种骨髓增殖性疾病的克隆起源而接受了检查。为了评估不同组织中的体细胞镶嵌现象，我们利用了正常葡萄糖-6-磷酸脱氢酶和地中海变体对葡萄糖-6-磷酸类似物2-脱氧葡萄糖-6-磷酸的不同利用率：结果表明，原发性血小板增多症是一种涉及红细胞系、粒细胞系和巨核细胞系的克隆性疾病，不影响单核细胞、T淋巴细胞和非T淋巴细胞。
