Hertig A T, MacKey J J, Feeley G, Kampschmidt K
Am J Obstet Gynecol. 1983 Apr 15;145(8):968-80. doi: 10.1016/0002-9378(83)90850-5.
Seventy-eight female reproductive tracts from mature Macaca fascicularis caught in the wild were examined histologically for evidence of dysplasia in immature (metaplastic) and native (mature) squamous epithelium of the cervix and vagina. This series contained equal numbers of experimental animals and control and/or breeding colony animals. Five of 39 experimental animals showed dysplasia, whereas six animals with definite and two with questionable dysplasia were found in 39 control and breeding colony animals. On the basis of the foregoing facts, it would appear that these dysplastic lesions were of spontaneous origin and of undetermined etiology. Therefore, those investigators who experiment upon the reproductive tract of this species of monkey should be wary of interpreting any given experiment as "causing" dysplasia. Monkeys of this same species, born and reared in our Primate Center, have been examined for comparable dysplastic lesions of the lower female genital tract. None was found thus far but the study is continuing.
对78例从野外捕获的成年食蟹猴的雌性生殖道进行了组织学检查，以寻找子宫颈和阴道未成熟（化生）及天然（成熟）鳞状上皮发育异常的证据。该系列中实验动物与对照和/或繁殖群体动物数量相等。39只实验动物中有5只出现发育异常，而在39只对照和繁殖群体动物中，发现6只明确有发育异常，2只可能有发育异常。基于上述事实，这些发育异常病变似乎是自发产生的，病因不明。因此，在用这种猴子的生殖道做实验的研究人员在将任何特定实验解释为“导致”发育异常时应谨慎。在我们的灵长类动物中心出生和饲养的同一物种的猴子，已对其雌性下生殖道类似的发育异常病变进行了检查。迄今为止尚未发现，但研究仍在继续。
