Narama I, Miura K, Tsuruta M, Tsuchitani M
Vet Pathol. 1985 Jul;22(4):355-62. doi: 10.1177/030098588502200410.
Splenic nodules from 38 cynomolgus monkeys (Macaca fascicularis) which were captured in Malaysia and Indonesia were studied histologically. The lesions were characterized by well-circumscribed focal fibrosis, accumulation of eosinophils and histiocytes, hemorrhage or hemosiderosis, and loss of normal splenic architecture. Small arteries in the lesion frequently had intimal thickening and narrowing of the lumen in addition to the presence of microfilariae. Microfilariae were also seen in the extravascular area of the lesion, and were occasionally engulfed by multinucleated giant cells. The splenic lesion was thought to have been initiated by incomplete infarction caused by intimal thickening and microfilarial occupation of the small arteries.
对从马来西亚和印度尼西亚捕获的38只食蟹猴（猕猴）的脾脏结节进行了组织学研究。病变的特征为界限清楚的局灶性纤维化、嗜酸性粒细胞和组织细胞聚集、出血或含铁血黄素沉着，以及正常脾脏结构丧失。病变中的小动脉除有微丝蚴外，常伴有内膜增厚和管腔狭窄。在病变的血管外区域也可见微丝蚴，偶尔被多核巨细胞吞噬。脾脏病变被认为是由小动脉内膜增厚和微丝蚴占据导致的不完全梗死引起的。
