Bahna S L, Heiner D C, Myhre B A
Allergy. 1983 Jan;38(1):57-64. doi: 10.1111/j.1398-9995.1983.tb00857.x.
Serum IgE levels in healthy blood donors who had no history of atopy were measured by a paper-disc RIA and analyzed according to the donors' smoking habits. The IgE geometric mean for regular smokers was 41.7 IU/ml, which was significantly higher than that for nonsmokers (19.3 IU/ml) or rare smokers (22.7 IU/ml). Whereas 28% of smokers had IgE levels greater than 200 IU/ml, none of the rare smokers or nonsmokers did. IgE levels in smokers showed a moderate inverse correlation with the degree of smoking. The mean IgE level was 189.8 IU/ml in those who smoked 1-9 cigarettes/day but only 32.8 IU/ml in those who smoked 10-19 cigarettes per day and 11.1 IU/ml in those who smoked 20 or more cigarettes/day. The number of years a person smoked did not seem to significantly influence the IgE level. The mean IgE level in ex-smokers (50.5 IU/ml) was much lower than in current light smokers but was still higher than in nonsmokers. There was a moderate inverse correlation between IgE levels and duration of cessation of smoking. Our data suggest a characteristic pattern for the influence of cigarette smoking on serum IgE level, namely, a striking rise associated with light smoking and a remarkable drop in heavy smokers, and such changes seemed reversible after the habit was stopped. Smoking status, therefore, appears to be an important consideration in interpreting serum IgE levels and in revising the "norms" of IgE levels.
采用纸盘放射免疫分析法测定无特应性病史的健康献血者的血清IgE水平，并根据献血者的吸烟习惯进行分析。经常吸烟者的IgE几何平均值为41.7 IU/ml，显著高于不吸烟者（19.3 IU/ml）或偶尔吸烟者（22.7 IU/ml）。28%的吸烟者IgE水平高于200 IU/ml，而偶尔吸烟者和不吸烟者均无此情况。吸烟者的IgE水平与吸烟程度呈中度负相关。每天吸1 - 9支烟者的平均IgE水平为189.8 IU/ml，而每天吸10 - 19支烟者为32.8 IU/ml，每天吸20支及以上者为11.1 IU/ml。一个人吸烟的年数似乎对IgE水平没有显著影响。既往吸烟者的平均IgE水平（50.5 IU/ml）远低于目前的轻度吸烟者，但仍高于不吸烟者。IgE水平与戒烟持续时间呈中度负相关。我们的数据表明吸烟对血清IgE水平的影响具有特征性模式，即轻度吸烟会显著升高，重度吸烟者则显著下降，而且在戒烟后这种变化似乎是可逆的。因此，吸烟状况似乎是解释血清IgE水平和修订IgE水平“正常范围”时的一个重要考虑因素。
