Salerno T A, Chiong M A
Ann Thorac Surg. 1983 Apr;35(4):367-71. doi: 10.1016/s0003-4975(10)61586-x.
The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium and endocardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.
本研究评估了一种临床使用的心脏停搏液对猪左心室能量储备的代谢影响。该心脏停搏液在心脏处于颤动（诱发心室颤动）状态或在主动脉钳夹前处于正常窦性心律时，被注入猪的升主动脉。与处于正常窦性心律的心脏相比，颤动的心脏在心外膜和心内膜中的糖原储备较低。心外膜和心内膜中，两种心脏的磷酸肌酸储备没有差异，但颤动心脏两层中的三磷酸腺苷（ATP）储备较低。这些结果表明，为实现理想的心肌保护，心脏停搏液应在体外循环下心脏跳动时注入，并且在交叉钳夹前诱发并维持的心室颤动可能会导致心肌损伤。
