Gundry S R, Burney R E, Thompson N W, Lloyd R
Arch Surg. 1983 May;118(5):529-32. doi: 10.1001/archsurg.1983.01390050013002.
The treatment of Hürthle cell neoplasms of the thyroid is controversial because of a lack of information about their clinical behavior and long-term follow-up. We reevaluated our experience of the past 33 years and compared our early experience with the more aggressive surgical approach used during the past ten years. We treated 62 patients with Hürthle cell neoplasm from 1949 through 1982. Twenty-six patients had benign neoplasms and 35 had malignant neoplasms proven by capsular or vascular invasion or nodal metastasis. Fourteen deaths were directly attributable to recurrent or metastatic disease, three among those with benign lesions. An aggressive surgical approach, involving total thyroidectomy or early-completion total thyroidectomy following lobectomy for all tumors histologically malignant or larger than 2 cm, resulted in a lower recurrence rate (21% v 59%) and fewer operations per patient (1.7 v 2.9) than in patients having other operations.
由于缺乏有关甲状腺许特耳细胞肿瘤临床行为和长期随访的信息，其治疗方法存在争议。我们重新评估了过去33年的经验，并将我们早期的经验与过去十年采用的更积极的手术方法进行了比较。1949年至1982年期间，我们治疗了62例许特耳细胞肿瘤患者。26例为良性肿瘤，35例经包膜或血管侵犯或淋巴结转移证实为恶性肿瘤。14例死亡直接归因于复发或转移性疾病，其中3例为良性病变患者。对于所有组织学上为恶性或大于2 cm的肿瘤，采用积极的手术方法，即全甲状腺切除术或在叶切除术后早期完成全甲状腺切除术，与接受其他手术的患者相比，复发率更低（21%对59%），每位患者的手术次数更少（1.7次对2.9次）。
