Ng T C, Daugherty J P, Evanochko W T, Digerness S B, Durant J R, Glickson J D
Biochem Biophys Res Commun. 1983 Jan 14;110(1):339-47. doi: 10.1016/0006-291x(83)91301-3.
Development of dose dependent chronic irreversible cardiotoxicity is a key problem encountered in chemotherapy with adriamycin. Here it has been demonstrated that infusion of this agent produced distinct and largely irreversible changes in levels of phosphate metabolites and substantial acidosis that are detected by 31P NMR of the Langendorf perfused heart. Administration of the antioxidant, butylated hydroxytoluene minimizes these spectral changes but does not substantially diminish the antineoplastic activity of adriamycin. Bisantrene (CL 216,942), a noncardiotoxic anthracene with antineoplastic activity, produces only minor perturbations of the 31P spectrum of the perfused rat heart. These studies demonstrate the potential utility of employing 31P NMR to monitor acute or chronic cardiotoxicity in the perfused rat heart and for developing noninvasive in vivo NMR techniques for monitoring cardiotoxicity in experimental animals and humans.
阿霉素化疗中出现的剂量依赖性慢性不可逆心脏毒性的发展是一个关键问题。在此已证明，输注该药物会使磷酸代谢物水平产生明显且基本不可逆的变化，并导致严重酸中毒，这可通过Langendorf灌注心脏的31P核磁共振检测到。给予抗氧化剂丁基化羟基甲苯可使这些光谱变化最小化，但不会显著降低阿霉素的抗肿瘤活性。双胺苯（CL 216,942）是一种具有抗肿瘤活性的无心脏毒性蒽类药物，对灌注大鼠心脏的31P光谱仅产生轻微扰动。这些研究证明了利用31P核磁共振监测灌注大鼠心脏急性或慢性心脏毒性以及开发用于监测实验动物和人类心脏毒性的非侵入性体内核磁共振技术的潜在效用。
