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马媾疫锥虫的特异性表面抗原:化学与物理研究

Variant specific surface antigens from Trypanosoma equiperdum: chemical and physical studies.

作者信息

Duvillier G, Aubert J P, Baltz T, Richet C, Degand P

出版信息

Biochem Biophys Res Commun. 1983 Jan 27;110(2):491-8. doi: 10.1016/0006-291x(83)91176-2.

DOI:10.1016/0006-291x(83)91176-2
PMID:6838532
Abstract

Nine variant specific surface antigens were purified from clones of Trypanosoma equiperdum and characterized by amino acid analysis, isoelectric focusing and circular dichroism. The molecules showed extensive differences in their isoelectric points, and by comparison with the corresponding amino acid compositions, this variation seemed to be due to different amide contents. Circular dichroism data allowed one to divide the molecules into 4 groups according to their respective percentages in alpha-helical and beta-sheet structure.

摘要

从马媾疫锥虫克隆株中纯化出9种变体特异性表面抗原,并通过氨基酸分析、等电聚焦和圆二色性进行表征。这些分子的等电点存在广泛差异,与相应的氨基酸组成相比,这种差异似乎是由于酰胺含量不同所致。圆二色性数据使人们能够根据它们在α-螺旋和β-折叠结构中的各自百分比将这些分子分为4组。

相似文献

1
Variant specific surface antigens from Trypanosoma equiperdum: chemical and physical studies.马媾疫锥虫的特异性表面抗原:化学与物理研究
Biochem Biophys Res Commun. 1983 Jan 27;110(2):491-8. doi: 10.1016/0006-291x(83)91176-2.
2
The variant surface glycoproteins of Trypanosoma equiperdum. Identification of a phosphorylated glycopeptide as the cross-reacting antigenic determinant.
FEBS Lett. 1983 Jul 11;158(1):174-8. doi: 10.1016/0014-5793(83)80702-9.
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Trypanosoma rhodesiense: chemical and immunological characterization of variant-specific surface coat glycoproteins.罗德西亚锥虫:变异特异性表面糖蛋白的化学与免疫学特性
Mol Biochem Parasitol. 1981 Aug;3(4):227-38. doi: 10.1016/0166-6851(81)90054-2.
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Purification of the variant antigens of Trypanosoma congolense: a new approach to the isolation of glycoproteins.
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Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.马媾疫锥虫可变表面抗原基因的基因组环境
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The control of variant surface antigen synthesis in trypanosomes.锥虫中变异表面抗原合成的调控
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引用本文的文献

1
Trypanosome variant-specific glycoproteins: a polygene protein family with multiple folding patterns?锥虫变体特异性糖蛋白:一个具有多种折叠模式的多基因蛋白家族?
Proc Natl Acad Sci U S A. 1984 Feb;81(4):998-1002. doi: 10.1073/pnas.81.4.998.
2
Molecular biology of trypanosome antigenic variation.锥虫抗原变异的分子生物学
Microbiol Rev. 1985 Jun;49(2):107-25. doi: 10.1128/mr.49.2.107-125.1985.