锥虫抗原变异的分子生物学 - Suppr

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Molecular biology of trypanosome antigenic variation.

作者信息

Donelson J E, Rice-Ficht A C

出版信息

Microbiol Rev. 1985 Jun;49(2):107-25. doi: 10.1128/mr.49.2.107-125.1985.

DOI:10.1128/mr.49.2.107-125.1985

PMID:2409439

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC373025/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec6/373025/53d15811da47/microrev00057-0018-a.jpg

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Molecular biology of trypanosome antigenic variation.锥虫抗原变异的分子生物学

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The IsTat 1.3 VSG multigene family in Trypanosoma brucei: retention of the expression linked copy through multiple antigenic switches.布氏锥虫中的IsTat 1.3 VSG多基因家族：通过多次抗原转换保留表达相关拷贝

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Expression of whole and hybrid genes in Trypanosoma equiperdum antigenic variation.马媾疫锥虫抗原变异中完整基因和杂交基因的表达

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引用本文的文献

Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.锥虫硫醇还原酶：抗锥虫和抗利什曼原虫药物设计的一个可行化疗靶点。

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Expression of a retroposon-like sequence upstream of the putative Trypanosoma brucei variant surface glycoprotein gene expression site promoter.布氏锥虫假定的可变表面糖蛋白基因表达位点启动子上游反转座子样序列的表达。

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A strand bias occurs in point mutations associated with variant surface glycoprotein gene conversion in Trypanosoma rhodesiense.在罗得西亚锥虫中，与变异表面糖蛋白基因转换相关的点突变存在链偏向性。

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A monocistronic transcript for a trypanosome variant surface glycoprotein.锥虫可变表面糖蛋白的单顺反子转录本。

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Bovine T cells specific for Trypanosoma brucei brucei variant surface glycoprotein recognize nonconserved areas of the molecule.针对布氏布氏锥虫变异表面糖蛋白的牛T细胞识别该分子的非保守区域。

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Metacyclic variant surface glycoprotein genes of Trypanosoma brucei subsp. rhodesiense are activated in situ, and their expression is transcriptionally regulated.布氏罗得西亚锥虫亚种的循环后期变异表面糖蛋白基因在原位被激活，且其表达受到转录调控。

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Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein.锥虫可变表面糖蛋白的翻译后修饰与细胞内运输

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本文引用的文献

A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein.布氏锥虫的一种可变表面糖蛋白，其合成时带有一个纯化糖蛋白中不存在的C末端疏水“尾”。

Nature. 1980 Dec 11;288(5791):624-6. doi: 10.1038/288624a0.

Analyses of variable antigen gene rearrangements in Trypanosoma brucei.布氏锥虫可变抗原基因重排分析

Am J Trop Med Hyg. 1980 Sep;29(5 Suppl):1037-42. doi: 10.4269/ajtmh.1980.29.1037.

The genes for variant antigens in trypanosomes.锥虫中变异抗原的基因。

Am J Trop Med Hyg. 1980 Sep;29(5 Suppl):1033-6. doi: 10.4269/ajtmh.1980.29.1033.

An introduction to antigenic variation in trypanosomes.锥虫抗原变异介绍

Am J Trop Med Hyg. 1980 Sep;29(5 Suppl):1027-32. doi: 10.4269/ajtmh.1980.29.1027.

Evidence for diploidy and mating in trypanosomes.锥虫中二倍体和交配的证据。

Nature. 1980 Oct 9;287(5782):536-8. doi: 10.1038/287536a0.

Sialic acids are responsible for charge heterogeneity of the variant surface glycoprotein of Trypanosoma congolense.

Mol Biochem Parasitol. 1981 Dec;4(3-4):129-38. doi: 10.1016/0166-6851(81)90012-8.

Trypanosoma congolense: surface glycoproteins of two early bloodstream variants. II. Purification and partial chemical characterization.

Exp Parasitol. 1981 Dec;52(3):427-39. doi: 10.1016/0014-4894(81)90102-8.

Two variant surface glycoproteins of Trypanosoma brucei have a conserved C-terminus.布氏锥虫的两种可变表面糖蛋白具有保守的C末端。

Nature. 1981;293(5829):230-3. doi: 10.1038/293230a0.

Purification of the variant antigens of Trypanosoma congolense: a new approach to the isolation of glycoproteins.

Biochim Biophys Acta. 1981 Mar 27;668(1):119-31. doi: 10.1016/0005-2795(81)90155-0.

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome.布氏锥虫表面抗原基因表达相关额外拷贝的基因组环境类似于染色体末端。

Nature. 1982 Sep 30;299(5882):451-3. doi: 10.1038/299451a0.

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