Caro C G, Lever M J
Atherosclerosis. 1983 Jan;46(1):137-46. doi: 10.1016/0021-9150(83)90172-7.
Experiments were undertaken on excised rabbit common carotid arteries to assess whether the distribution volume for radioactively labelled albumin is influenced by smooth muscle tone or externally applied stress. In arteries at relaxed length and zero transmural pressure, the distribution volume in the media was reduced by noradrenaline at concentrations exceeding 10(-9) M and increased by both sodium nitrite and isosorbide dinitrate at concentrations exceeding 10(-4) M. The distribution volume was lower in both the media and adventitia of segments at in vivo length pressurized with air to prevent convection through the wall, than in segments at relaxed length and zero transmural pressure. Noradrenaline decreased and sodium nitrite increased the medial distribution volume of the tracer in these air-pressurized segments. The vasoactive agents did not change the [51Cr]EDTA space in vessels at relaxed length and zero transmural pressure, although there were small alterations of medial water content. Transient conditions raise interpretative difficulties because of uncertainty about endothelial permeability and time-dependent changes of wall properties. The changes of the distribution volume for labelled albumin are thought to reflect changes in the properties of the interstitium.
对切除的兔颈总动脉进行实验，以评估放射性标记白蛋白的分布容积是否受平滑肌张力或外部施加压力的影响。在处于松弛长度和零跨壁压力的动脉中，当去甲肾上腺素浓度超过10（-9）M时，中膜的分布容积减小；当亚硝酸钠和硝酸异山梨酯浓度超过10（-4）M时，中膜的分布容积增加。对于用空气加压至体内长度以防止通过血管壁对流的节段，其在中膜和外膜的分布容积均低于处于松弛长度和零跨壁压力的节段。在这些空气加压节段中，去甲肾上腺素降低、亚硝酸钠增加示踪剂在中膜的分布容积。血管活性药物并未改变处于松弛长度和零跨壁压力的血管中的[51Cr]EDTA空间，尽管中膜含水量有小的改变。由于内皮通透性不确定以及血管壁特性随时间的变化，瞬态情况会增加解释难度。标记白蛋白分布容积的变化被认为反映了间质特性的变化。
