Owen H, Hunter A R
Br J Anaesth. 1983 Apr;55(4):315-8. doi: 10.1093/bja/55.4.315.
Three hundred and thirty-two patients undergoing electroconvulsive therapy received thiopentone and suxamethonium. In 31 the duration of the apnoea was greater than an assumed upper limit of normal of 240 s. Eight of these patients proved, on biochemical grounds, to be heterozygotes for the atypical gene. The reason why the heterozygous state is rarely present in those who have prolonged apnoea is that the vast majority of those who suffer from this abnormality are only slightly more sensitive to suxamethonium than are normal individuals.
332例接受电休克治疗的患者使用了硫喷妥钠和琥珀酰胆碱。其中31例患者的呼吸暂停持续时间超过了假定的正常上限240秒。根据生化检测结果，这些患者中有8例为非典型基因的杂合子。杂合状态在呼吸暂停延长患者中很少见的原因是，绝大多数患有这种异常的患者对琥珀酰胆碱的敏感性仅比正常个体略高。
