O'Connor W N, Hamann S R, Hanley H G
Br J Exp Pathol. 1983 Feb;64(1):81-6.
Experimental myocardial infarction of the posterolateral left ventricular wall in 2 dog hearts, the result of 1 h of occlusion of the left circumflex coronary artery followed by 4 days of reperfusion, was studied post mortem by serial histological sectioning. Microscopic examination in a transverse plane showed a zone of apparent necrotic muscle removal which formed a continuous boundary between necrotic and normal myocardium without outlying, detached "islands" of necrosis. Reconstruction of the histological transmural edge of infarction at its interface with viable subepicardial muscle demonstrated wide overlapping and angulated interdigitation of the separated tissues across the midzone of the ventricular wall. The observed 3-dimensional spatial complexity of the transmural infarct boundary may be a limiting factor in successful evaluation of this experimentally important region.
对2只犬心脏左心室后外侧壁进行实验性心肌梗死研究，通过闭塞左旋冠状动脉1小时后再灌注4天造成心肌梗死，死后通过连续组织切片进行研究。横切面显微镜检查显示有一个明显的坏死心肌清除区域，该区域在坏死心肌和正常心肌之间形成了连续边界，没有外围孤立的坏死“岛”。梗死组织学透壁边缘与存活的心外膜下心肌交界处的重建显示，分离组织在心室壁中层区域广泛重叠并呈角状交错。观察到的透壁梗死边界的三维空间复杂性可能是成功评估这个实验重要区域的一个限制因素。
