Factor S M, Sonnenblick E H, Kirk E S
Am J Pathol. 1978 Jul;92(1):111-24.
Observation of isolated islands of apparently surviving myocardium within areas of necrotic tissue at the edge of myocardial infarctions has been interpreted by some as histologic evidence of a unique "border zone" region. Serial section reconstruction of transmural canine myocardial infarctions was performed in this study to establish whether these islands were truly isolated or were continuous peninsulas of tissue separated by the plane of section. Three-dimensional analysis of the infarcts revealed no true islands but instead demonstrated a region composed of highly complex interdigitating peninsulas. We conclude that there is an extremely irregular but sharp boundary demarcating normal and infarcted myocardium with no intermediate zone. This observation is discussed in relation to recent data, based on coronary blood flow and creatine phosphokinase analysis, which also demonstrates a sharp boundary between the normal and infarct zones.
在心肌梗死边缘坏死组织区域内观察到明显存活的心肌孤岛，一些人将其解释为独特“边界区”的组织学证据。本研究对犬透壁性心肌梗死进行了连续切片重建，以确定这些孤岛是真正孤立的，还是被切片平面分隔的连续组织半岛。对梗死灶的三维分析显示没有真正的孤岛，而是一个由高度复杂的相互交错的半岛组成的区域。我们得出结论，正常心肌和梗死心肌之间存在一个极其不规则但清晰的边界，没有中间带。结合最近基于冠状动脉血流和肌酸磷酸激酶分析的数据对这一观察结果进行了讨论，这些数据也表明正常区和梗死区之间存在清晰的边界。
