Riccioppo Neto F
Br J Pharmacol. 1983 Mar;78(3):529-32. doi: 10.1111/j.1476-5381.1983.tb08812.x.
1 The effects of the venom of the scorpion (Tityus serrulatus) on nerve fibres of the rabbit cervical vagus were studied by the single sucrose-gap technique. Scorpion venom (1 microgram/ml) increased irreversibly the duration of the B component of the compound action potential of the vagus nerves, leaving the C component with its normal configuration. Tetrodotoxin (200 nM) suppressed the prolongation of the action potential duration in venom-treated B fibres. 2 At the same concentration (1 microgram/ml), scorpion venom reduced the amplitude and the rate constant of decay of the hyperpolarization produced by tetanic stimulation of non-myelinated nerve fibres. 3 A lower concentration (0.2 micrograms/ml) blocked completely the hyperpolarization of the potassium-activated response. After washing, the potassium-activated response partially recovered its amplitude but there was a significant increase in the time constant of the decay of hyperpolarization. 4 It is suggested that scorpion venom may modify the sodium pumping mechanism within fibres as well as affecting the passive and active sodium permeability systems.
采用单蔗糖间隙技术研究了蝎子（锯齿脂鲤属）毒液对家兔颈迷走神经纤维的影响。蝎毒（1微克/毫升）不可逆地增加了迷走神经复合动作电位B成分的持续时间，而C成分保持正常形态。河豚毒素（200纳摩尔）抑制了毒液处理的B纤维中动作电位持续时间的延长。
在相同浓度（1微克/毫升）下，蝎毒降低了强直刺激无髓神经纤维产生的超极化的幅度和衰减速率常数。
较低浓度（0.2微克/毫升）完全阻断了钾激活反应的超极化。冲洗后，钾激活反应部分恢复其幅度，但超极化衰减的时间常数显著增加。
提示蝎毒可能改变纤维内的钠泵机制，以及影响被动和主动钠通透性系统。
